Poster ID:1142065641

APPLICATIONS OF IMAGING MATRIX ASSISTED LASER DESORPTION IONISATION - MASS SPECTROMETRY TO THE STUDY OF DERMAL ABSORPTION OF ISOCYANATES

click image to enlarge APPLICATIONS OF IMAGING MATRIX ASSISTED LASER DESORPTION IONISATION - MASS SPECTROMETRY TO THE STUDY OF DERMAL ABSORPTION OF ISOCYANATES


Author:Brendan Prideaux

Co-authors: Malcolm R. Clench, Vikki A. Carolan, Jackie Morton

Abstract/Description:
Isocyanates are commonly used in industry in the manufacture of polyurethane products such as foams, paints and plastics. They are highly reactive compounds, known to produce adverse effects in humans after exposure[1+2]. Dermal exposure is of particular concern although the mechanisms of this are poorly understood.rnrnIn the work described here the dermal penetration of isocyanates was investigated using Matrix Assisted Laser Desorption Ionisation - Time of Flight - Mass Spectrometry. MALDI-TOF-MS has been previously used to investigate such low molecular weight compounds present in skin[3]. Imaging software enables the distribution of the analytes in the skin to be observed, and thus any dermal penetration to be detected

Poster presented at:
3rd National Meeting on Environmental Mass Spectrometry - 2006


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