Novel Applications of MALDI-TOF: Recent advances in the profiling of microorganisms

Author:Vic Parr

Co-authors:David Evason, Alexis Polley

Abstract/Description:
Imaging MALDI (I-MALDI) is becoming a popular application to MALDI-TOFMS. I-MALDI charts the distribution of biomarkers, (be they peptides, proteins or other MALDI ionisable compounds), on the surface of solid samples. The applications are varied including mass spectral comparisons of biomarker distribution within diseased and healthy tissues. Recently We at SAI have investigated the use of this powerful tool or the identification of microorganisms sampled from culture. Examples are given of different stains of MRSA imaged directly from a glass sample slide.

Poster presented at:
3rd National Meeting on Environmental Mass Spectrometry - 2006